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| reverse pharmacology ： ウィキペディア英語版 |
reverse pharmacology
In the field of drug discovery, reverse pharmacology also known as target base drug discovery (TDD), a hypothesis is first made that modulation of the activity of a specific protein target will have beneficial therapeutic effects. Screening of chemical libraries of small molecules is then used to identify compounds that bind with high affinity to the target. The hits from these screens are then used as starting points for drug discovery. This method became popular after the sequencing of the human genome which allowed rapid cloning and synthesis of large quantities of purified proteins. This method is the most widely used in drug discovery today.
== See also ==
* Classical pharmacology
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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